iCo Therapeutics Begins Trading on the OTCQX Marketplace

December 20, 2013, Vancouver, Canada—iCo Therapeutics (TSX-V: ICO) (OTCQX: ICOTF), announced that its common shares will begin trading today on OTCQX International, a segment of the OTCQX marketplace in the U.S., under the symbol “ICOTF.” iCo’s common shares will also continue to trade on the TSX Venture Exchange under the symbol “ICO”.

iCo expects to benefit from trading on OTCQX by gaining greater exposure and increasing liquidity in the United States, the location of all clinical sites for its ongoing Phase 2 iDEAL study for diabetic macular edema (DME).

“We look forward to increasing awareness of the Company’s ongoing clinical developments and progress in the United States, the single most important biotechnology investor market globally, by trading on the OTCQX marketplace,” said Andrew Rae, President & CEO of iCo Therapeutics.

OTCQX International, a segment of the OTCQX marketplace, is reserved for high-quality non-U.S. companies that are listed on a qualified international exchange and provide their home country disclosure to U.S. investors. U.S. investors can find current financial disclosures and Real-Time Level 2 quotes for the company on www.otcmarkets.com.

Troutman Sanders LLP will serve as iCo Therapeutics’ Principal American Liaison (“PAL”) on OTCQX, responsible for providing professional guidance on OTCQX requirements and U.S. federal securities laws.

About OTC Markets Group Inc.

OTC Markets Group Inc. operates Open, Transparent and Connected financial marketplaces for 10,000 U.S. and global securities. Through its OTC Link® ATS, they directly link a diverse network of broker-dealers that provide liquidity and execution services for a wide spectrum of securities. The company organizes these securities into marketplaces to better inform investors of opportunities and risks — OTCQX®, The Best Marketplace with Qualified Companies; OTCQB®, The Venture Stage Marketplace with U.S. Reporting Companies; and OTC Pink®, The Open Marketplace with Variable Reporting Companies. OTC Markets Group’s data-driven platform enables investors to easily trade through the broker of their choice at the best possible price and empowers a broad range of companies to improve the quality and availability of information for their investors. To learn more about OTC Markets Group, visit www.otcmarkets.com.

About iCo Therapeutics

iCo Therapeutics in-licenses and redefines existing drug candidates or generics by employing reformulation and delivery technologies for new or expanded use indications. The company has exclusive worldwide rights to two drug candidates – iCo-007 for Diabetic Macular Edema (DME) and iCo-008 for other sight-threatening diseases. iCo-007 is in Phase 2 clinical studies for DME. With Phase 2 clinical history, iCo-008 is targeted for the treatment of keratoconjunctivitis and wet age-related macular degeneration. In addition, iCo holds worldwide rights to an oral drug delivery platform. The first platform candidate is the Oral Amp B Delivery system, utilizing a known anti-fungal drug to treat life-threatening infectious diseases.  iCo trades on the TSX Venture Exchange under the symbol “ICO” and the OTCQX under the symbol “ICOTF”.  For more information, visit the Company website at: icotherapeutics.cdmail.biz.

No regulatory authority has approved or disapproved the content of this release. The TSX Venture Exchange does not accept responsibility for the adequacy or accuracy of this release.

Forward Looking Statements

Certain statements included in this press release may be considered forward-looking statements” within the meaning of the safe harbor provisions of the U.S. Private Securities Litigation Reform Act of 1995. Forward-looking statements can be identified by words such as: “anticipate,” “intend,” “plan,” “goal,” “seek,” “believe,” “project,” “estimate,” “expect,” “strategy,” “future,” “likely,” “may,” “should,” “will,” and similar references to future periods. Such statements involve known and unknown risks, uncertainties and other factors that may cause actual results, performance or achievements to be materially different from those implied by such statements, and therefore these statements should not be read as guarantees of future performance or results. All forward-looking statements are based on iCo’s current beliefs as well as assumptions made by and information currently available to iCo and relate to, among other things, anticipated financial performance, business prospects, strategies, regulatory developments, market acceptance and future commitments. Readers are cautioned not to place undue reliance on these forward-looking statements, which are based only on information currently available to iCo and speak only as of the date of this press release. Due to risks and uncertainties, including the risks and uncertainties identified by iCo in its public securities filings and on its website, actual events may differ materially from current expectations. iCo disclaims any intention or obligation to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise.

Mr. John Meekison, CFO
iCo Therapeutics
604-602-9414 x 224
meekison@icotherapeutics.cdmail.biz
Michael Moore, Investor Relations
TMX Equicom
858-886-7813
mmoore@tmxequicom.com