VANCOUVER, Canada— iCo Therapeutics Inc. (TSX-V: ICO) is pleased to announce that early results for iCo’s Diabetic Macular Edema (DME) candidate, iCo-007, will be highlighted in a presentation at a prominent ocular conference.
The presentation will be given by Geeta A. Lalwani, MD, Assistant Professor of Clinical Ophthalmology, Vitreoretinal Diseases and Surgery at the Bascom Palmer Eye Institute University of Miami Miller School of Medicine. The Bascom Palmer Eye Institute is one of the premier eye centres in the world, and one of the four U.S. sites conducting iCo’s ongoing iCo-007 clinical trial. Along with Philip Rosenfeld, MD, Dr. Lalwani is an investigator participating in the Phase I clinical trial in DME patients. The primary endpoint of the open label, dose escalating trial is safety, with visual acuity and measures of retinal thickness serving as secondary endpoints.
The conference, “Angiogenesis, Exudation and Degeneration 2009”, will be held on Saturday, February 21, 2009 at the Ritz-Carlton Key Biscayne. The conference will feature prominent scientists, clinicians and healthcare experts in neovascular diseases of the eye, including AMD and DME. Dr. Lalwani’s presentation will be held at 4:25pm.
iCo-007 is expected to decrease swelling in the retina and related visual impairment by decreasing the signaling of multiple growth factors, including VEGF, IGF, bFGF, EPO and HGF that signal through the c-Raf kinase / MAP kinase pathway. iCo-007 may also be a potential treatment for certain oncology indications, as c-Raf kinase is the predominant Raf isoform responsible for regulating cellular growth in ovarian cancer. iCo-007 is an antisense drug discovered by Isis Pharmaceuticals, Inc. (Nasdaq: ISIS) and licensed to iCo Therapeutics for the treatment of various eye diseases.
About iCo Therapeutics Inc.
iCo Therapeutics Inc. is a Vancouver-based development based company focused on in-licensing drugs with clinical history redosing or reformulating for new or expanded indications. iCo has exclusive worldwide rights to three products. iCo-007, a second generation antisense candidate licensed from Isis Pharmaceuticals, is currently in a Phase I trial in Diabetic Macular Edema patients with compelling early data. iCo-008 is a human monoclonal antibody targeting eotaxin-1 with Phase II clinical history, licensed from AstraZeneca/MedImmune. iCo-009 is a proprietary oral formulation of amphotericin B licensed from the University of British Columbia. To date, iCo has reported positive preclinical results for iCo-009. iCo Therapeutics trades on the TSX-Venture exchange under the symbol “ICO”. For more information, visit the company website at: https://icotherapeutics.com
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